Synthesis Of P Hydroxy Acetanilide - 1067 Words

Synthesis of P-Hydroxy Acetanilide (Paracetamol) Kirstie Leckie B00266969 Abstract In this experiment the aim was to obtain a pure sample of paracetamol by reduction of p-aminophenol with acetic anhydride. The process carried out to obtain the paracetamol included mixing p-aminophenol, the starting product, with acetic anhydride suspended in distilled water until a precipitate formed (the product). The product was filtered, dried and recrystallized to purify. Infra red spectra for the starting product and the recrystallized and dried product were obtained and compared, and a TLC was run comparing the starting and finishing material. The melting point range of the final product was measured and compared to the literature melting point. Introduction P-Hydroxy acetanilide (paracetamol), molecular formula C8H9NO2, is a painkilling drug (analgesic). It works as a painkiller by inhibiting pain pathways in the central nervous system and in turn dampens the body’s natural pain response. Paracetamol is also fever reducing (antipyretic) and has a relatively low risk of side-effects when taken in recommended doses - it is however potentially toxic in large doses and can lead to acute liver failure (. For it’s antipyretic and analgesic properties, paracetamol is a widely used over the counter medicine for treatment of minor aches and pains, as well as to reduce fevers (Prescott, 2001). Paracetamol was first synthesised in 1873 by Harmon Northrop Morse by reducing p-aminophenolShow MoreRelatedElectrophilic Aromatic Substitution2520 Words   |  11 Pageshalogens are ortho- and para- directing deactivators. The activation or deactivation of the benzene ring toward electrophilic attack, and electron withdrawing substituents deactivate the ring. Using the reagents benzene, chlorobenzene, aspirin, acetanilide, p-nitrophenol, anisole and phenol in ethyl acetate, we will observe the bromination rate and will classify as either activator or deactivator. In performing the experiment, 0.20 ml of bromine solution will be added in each solution. In general